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Sepsis: New Insights, New Therapies (PDF) | 10 MB
Published in 2007 by John Wiley & Sons Ltd
Contents
Symposium on Sepsis: new insights, new therapies, held at the Novartis Foundation,
London, 14?16 February 2006
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Mitchell Fink and Mervyn Singer
Mitchell P. Fink Chair?s introduction 1
Discussion 4
Alessandro Protti and Mervyn Singer Strategies to modulate cellular
energetic metabolism during sepsis 7
Discussion 16
Jérôme Pugin Immunostimulation is a rational therapeutic strategy in
sepsis 21
Discussion 27
Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl,
Joanne L. Lomas-Neira, Ryan Swan and Chun-Shiang Chung
Blockade of apoptosis as a rational therapeutic strategy for the treatment of
sepsis 37
Discussion 49
John C. Marshall, Zeenat Malam and Songhui Jia Modulating neutrophil
apoptosis 53
Discussion 67
Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Tracey and
Andrew E. Sama HMGB1 as a potential therapeutic target 73
Discussion 85
Csaba Szabó Poly (ADP-ribose) polymerase activation and circulatory
shock 92
Discussion 103
Xavier Leverve, Cécile Batandier and Eric Fontaine Choosing the right
substrate 108
Discussion 121
Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel,
Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen,
Simon J. Foster, Muhammad M. Yaqoob and Christoph
Thiemermann Inhibiting glycogen synthase kinase 3ß in sepsis 128
Discussion 142
Mitchell P. Fink Ethyl pyruvate: a novel treatment for sepsis 147
Discussion 156
General discussion I 160
Stefan W. Ryter and Augustine M. K. Choi Cytoprotective and
anti-infl ammatory actions of carbon monoxide in organ injury and sepsis
models 165
Discussion 175
Andrea Polito, Jérôme Aboab and Djillali Annane The hypothalamic
pituitary adrenal axis in sepsis 182
Discussion 199
Ilse Vanhorebeek, Lies Langouche and Greet Van den Berghe Modulating
the endocrine response in sepsis: insulin and blood glucose control 204
Discussion 215
Luis Ulloa and Ping Wang The neuronal strategy for infl ammation 223
Discussion 233
C. T. Pereira, M. G. Jeschke and D. N. Herndon Beta-blockade in
burns 238
Discussion 248
Mervyn Singer System interactions 252
Discussion 262
C. A. Piantadosi, M. S. Carraway, D. W. Haden and H. B. Suliman
Protecting the permeability pore and mitochondrial biogenesis 266
Discussion 276
Contributor index 281
Subject index 283
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