As an infectious disease specialist, Dr. Gregory House (Hugh Laurie) is a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives. House solves the inexplicable cases that other doctors cannot understand.

House isn't alone in this quest. His team includes neurologist Dr. Eric Foreman (Omar Epps), a neurologist with a troubled youth and a desire to avoid becoming as abrasive as House; immunologist Dr. Allison Cameron (Jennifer Morrison) - who sometimes cares too much and has conflicting feelings about House; and Dr. Robert Chase (Jesse Spencer), a specialist in intensive care who has lived a very privileged life. House's good (and possibly only) friend Dr. James Wilson (Robert Sean Leonard) is an oncology specialist, who has to help and stand up for House on a regular basis, while trying to get him to face a few harsh truths.

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As a total eclipse casts a shadow across the globe, a genetics professor, Mohinder Suresh, is motivated by his father?s mysterious disappearance to delve into his missing father?s secret theory ? there are people with unique and special abilities among us.

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Set in Washington, DC, Day 7 opens with CTU dismantled and Jack Bauer (Kiefer Sutherland) on trial. Bauer?s day takes an unexpected turn when former colleague Tony Almeida (Carlos Bernard) returns. Meanwhile, President Allison Taylor (Cherry Jones) leads the country alongside White House Chief of Staff Ethan Kanin (Bob Gunton) and First Gentleman Henry Taylor (Colm Feore).

A national security crisis prompts an investigation by a team of FBI agents including Agent Janis Gold (Janeane Garofalo), Agent Renee Walker (Annie Wersching), Agent Larry Moss (Jeffrey Nordling), Agent Sean Hillinger (Rhys Coiro) and security specialist Michael Latham (John Billingsley). Although CTU is no longer, Chloe O?Brian (Mary Lynn Rajskub) and Bill Buchanan (James Morrison) are back for another momentous day of shocking events.

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