| |
 Science, March 28, 2008PDF | English | 25.3 MB
Cover
The many layers of gene regulation in a eukaryotic cell, envisioned as a video game. Transcription in the nucleus (green circle) proceeds to translation in the cytoplasm via genome topology, polymerase pausing, microRNA repression, RNA splicing, and riboswitch regulation.
Special Issue: Gene Regulation
As in civil society, where there must necessarily be checks and balances on freedom of expression, cells have evolved a range of mechanisms to regulate the expression of their constituent genes. By far the best-understood medium for gene regulation is the protein transcription factor. However, new and unexpected gene regulatory systems have been discovered in the past decade, perhaps the most important of which involve microRNAs (miRNAs).
Science by the Masses
By offering prizes on behalf of clients seeking scientific and engineering help, an Internet company called InnoCentive has gathered a virtual work force of 135,000 problem-solvers from around the world.
With New Disease Genes, a Bounty of Questions
New techniques, including genome-wide associations, are identifying new disease risk factors; researchers are uncertain what they mean -- and what to advise patients.
Lunar and Planetary Science Conference
At the Lunar and Planetary Science Conference, cosmochemists reported measurements of the oxygen isotopic composition of the sun that indicate that isotopically as well as physically, Earth is not at the center of things.
Dynamics of Saturn's South Polar Vortex
Observations from Cassini show that the cloud vortex at Saturn?s south pole shares some features with hurricanes (such as an eye wall), but forms by a different mechanism.
---------- For countries, US, DE, ES, GB, FR, IT, CA, PT, NL, BE, RU, download hereFor other countries, download here
Related NewsThe Gene Wars: Science, Politics, And The Human GenomeGenes VIIIScience, January 18, 2008Science, November 30, 2007Science, April 11, 2008 |
|
