Open Platform & Open Source.
PortableApps.com provides a truly open platform that works with any hardware you like (USB flash drive, iPod, portable hard drive, etc). The entire platform is open source built around an open format that any hardware or software provider can use.
Programs List
Graphics:
IconWorkshop Portable 6.53
ImageResizer Portable 4.0.3.2
ImageShack Uploader Portable 2.2.0
Inkscape Portable 0.48
PhotoFiltreStudio Portable 10.3.2
PhotoZoom Pro Portable 4.0.4
Picasa Portable 3.8.117.29

Multimedia:
DVDFab Portable 8.0.6.5
DVD Converter Portable 4.1.7
GoldWave Portable 5.58 En
HyperSnap Portable 6.83.02
IsoBuster Portable 2.8.5.0
JetAudio Portable 8.0.11.1600 Plus VX
KMPlayer Portable 3.0.0.1439
Reaper Portable 3.74 32-bit
Video Converter Portable 3.1.7

Utility:
WinMount 3.4.0804
GetDataBack 4.10 for Fat and NTFS
GoogleEarth Plus Portable 5.2.1.1588
HDInspector Portable 3.87.393
TagRename Portable 3.5.7
TotalCommander Portable 7.56a
TuneUp Portable 10.0.3000.101
WinRAR Portable 4.00 beta 3 32-64 Bit
Xplorer2 Portable 1.8.1.1 32-64-bit

Office:
PDF Editor 2.2.1.1119
FoxitReader 4.3.0.1110
AbiWord Portable 2.8.6
Atlantis Portable 1.6.5.3 En
Babylon Portable 8.1.0.16

Internet:
Skype 5.0.0.156
AIMP Portable 3.0.0.810
FileZilla Portable 3.3.5.1
Firefox Portable 4.0b8
HTTrack Portable 3.43-12 (32-64 Bit)
JDownloader Portable 0.9.580
LimeWire Portable 5.5.16
OrbitDownloader Portable 4.0.0.5
TheBat Portable 4.2.38.6
WeBuilder Portable 10.2 En-De
Thunderbird Portable 3.1.7

System:
AIDA64 Extreme Portable 1.50.1200
DriverMagician Portable 3.52
Java Portable 1.6.0 22
Malwarebytes Portable 1.50.1.1100
Notepadpp Portable 5.8.6
Plugins Portable Flash 10.1.102.64

How to installs: Just extract to any where you like and run for it.